What’s The Connection Between Hormones And Mood?

hormones and mood

The relationship between a woman’s hormones and mood is a subject of interest in the field of women’s health. Hormones play a pivotal role in regulating a woman’s emotional well-being throughout her life, influencing mood fluctuations during the menstrual cycle, pregnancy, postpartum, perimenopause, and menopause. 

Women’s Hormones And Mood

In women, hormones not only regulate fertility but also play a significant role in influencing brain chemistry, mental well-being, and mood. Among these hormones, estrogen, progesterone, and testosterone play pivotal roles in shaping both women’s health and emotional states. At Kernodle OB/GYN, we are here to dissect the connection between a woman’s hormones and mood. 

Hormonal Fluctuations During The Menstrual Cycle

One of the most well-known aspects of the connection between hormones and mood in women is the impact of hormonal fluctuations during the menstrual cycle. The menstrual cycle involves a complex interplay of hormones, primarily estrogen and progesterone. These hormonal changes can lead to various mood-related symptoms:

Premenstrual Syndrome (PMS): 

Many women experience mood swings, irritability, anxiety, and even depression in the days leading up to menstruation. This is often attributed to the drop in estrogen and progesterone levels during this phase.

Menstrual-Related Mood Disorders

For some women, these mood symptoms can become more severe, leading to conditions like premenstrual dysphoric disorder (PMDD), which can significantly affect their emotional well-being.

Pregnancy And Postpartum Mood Changes

The hormonal changes during pregnancy and the postpartum period are another critical aspect of the connection between hormones and mood:


The hormonal rollercoaster of pregnancy can lead to mood swings, emotional sensitivity, and heightened stress. Estrogen and progesterone levels increase significantly, and women may experience mood changes due to these hormonal shifts.

Postpartum Depression

After childbirth, women often experience the “baby blues,” characterized by mood swings, sadness, and irritability. Some women, however, develop more severe mood disorders like postpartum depression, which can be linked to hormonal fluctuations, sleep deprivation, and the profound life changes associated with motherhood.

Perimenopause and Menopause

As women approach perimenopause and menopause, they go through substantial hormonal changes that can affect their mood:


During the years leading up to menopause, estrogen levels begin to decline. This hormonal shift can lead to mood swings, irritability, and increased susceptibility to stress. Some women may also experience symptoms like hot flashes and night sweats, which can further impact their sleep and mood.


When a woman reaches menopause (the cessation of menstrual periods), estrogen and progesterone levels drop significantly. This hormonal shift can contribute to mood changes, including symptoms of depression and anxiety.

Managing Mood Fluctuations

Understanding the connection between hormones and mood is crucial for women’s well-being. While hormonal fluctuations can have a significant impact on mood, there are a number of strategies to help manage these changes:

Lifestyle Modifications

Engaging in regular exercise, maintaining a healthy diet, getting adequate sleep, and managing stress through relaxation techniques such as meditation or yoga can all help stabilize mood.


In cases of severe mood symptoms associated with hormonal fluctuations, healthcare providers may recommend medications like antidepressants or hormonal therapies (ex., hormonal birth control) to help regulate mood.

Counseling and Therapy

Cognitive-behavioral therapy (CBT) and other forms of counseling can be effective in helping women cope with mood-related symptoms. Therapy can provide valuable tools for managing stress, anxiety, and mood swings.

Hormone Replacement Therapy (HRT)

In some cases, healthcare providers may recommend hormone replacement therapy (HRT) for women experiencing severe mood disturbances associated with menopause. HRT aims to restore hormonal balance and alleviate symptoms.


While hormonal fluctuations can significantly impact mood, there are various strategies available to help manage these changes effectively. Here at Kernodle OB/GYN, we provide full-scope individualized women’s health care, including gynecological care, midwifery services, and low- and high-risk maternity care for women and their families. If you have more questions about hormones and mood, call Kernodle OB/GYN at (336) 538-2367 to make an appointment.

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